功能和结构连接性下降与自闭症谱系障碍儿童在迷你篮球训练计划后核心症状改善有关
Dongyue Zhou1, Zhimei Liu2, Guanyu Gong3
1School of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian, China.
Journal of autism and developmental disorders
|October 26, 2023
概括
迷你篮球训练通过降低大脑网络连接来改善自闭症谱系障碍 (ASD) 儿童的核心症状. 这种运动干预可以帮助正常化ASD中的神经解剖学.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 康复医学 康复医学 康复医学
背景情况:
- 自闭症谱系障碍 (ASD) 的核心症状可以通过运动干预来改善.
- 在ASD中运动带来的好处背后的精确神经机制仍然不清楚.
- 了解这些机制对于开发有效的治疗策略至关重要.
研究的目的:
- 研究12周迷你篮球训练计划 (MBTP) 对ASD儿童大脑功能和结构网络的影响.
- 检查MBTP诱导的网络变化与ASD核心症状的改善之间的关联.
- 为了探索MBTP是否可以推动大脑变化,以一种更典型的神经解剖学模式.
主要方法:
- 进行了为期12周的MBTP干预,对32名患有自闭症儿童 (3-12岁) 进行了治疗.
- 干预前后收集了结构性MRI和静止状态功能性MRI数据.
- 基于个体的方法被用来构建和分析功能和结构性脑网络.
- 一组26名患有自闭症儿童的对照组没有接受任何特殊干预.
主要成果:
- 经过MBTP干预,传感器运动网络内部以及传感器运动和突出网络之间的功能连接性下降.
- 在特定的皮质-皮质和皮质下皮质-皮质网络中观察到形态连接强度的显著减少.
- 这些功能和结构性大脑变化与核心ASD症状的改善有关.
- 对照组没有显示可比的网络变化.
结论:
- MBTP是改善ASD儿童核心症状的有希望的干预措施.
- 这种干预似乎调节大脑网络连接,将其减少到更典型的模式.
- 在功能和结构性大脑网络中,运动诱导的变化与ASD的症状改善有关.
- MBTP可能有助于正常化ASD儿童的神经解剖学.
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