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聚乙烯糖醇甲状腺刺激激素 (PEG-TSH) 测试用于治疗儿科甲状腺功能障碍

Hussein Zaitoon¹, Gabi Shefer², Anat Segev-Becker¹

¹The Institute of Pediatric Endocrinology and Diabetes, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, affiliated to the Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

|October 26, 2023

概括

聚乙烯糖醇 (PEG) -甲状腺刺激激素 (TSH) 测试有助于澄清儿童的甲状腺功能. 这种方法有助于通过准确评估TSH水平来避免不必要的甲状腺激素治疗.

科学领域:

儿科内分泌学儿科内分泌学
临床化学临床化学
实验室医学实验室医学

背景情况:

甲状腺刺激激素 (TSH) 测试可能存在不一致性,特别是在儿科患者群体中.
提升的TSH和正常的自由甲状腺素 (FT4) 之间的差异需要进一步调查.

研究的目的:

评估聚乙烯糖醇 (PEG) -TSH测试在儿科患者中的实际应用.
评估其在管理高TSH和正常FT4水平的病例中的有用性.

主要方法:

一项使用第三级医疗中心电子数据库的观察性研究.
在儿科患者 (2015-2023) 中进行的TSH和PEG-TSH测试的分析.
以PEG-TSH结果为指导的临床和生化特征和管理的评估.

主要成果:

在2949个TSH测试中,61个 (2.1%) 是38名儿科患者的PEG-TSH测试.
与亚临床甲状腺功能障碍症和哈希莫托甲状腺炎相比,先天性甲状腺功能障碍症的病例显示TSH和PEG-TSH水平显著更高.
在TSH和PEG-TSH水平之间观察到强烈的相关性 (r=0.871),在近一半的病例中影响了临床决策.

结论:

PEG-TSH测试对于在儿童和青少年中准确确定TSH水平非常有价值.
它有助于防止不必要的甲状腺激素治疗.
管理可以根据正常的PEG-TSH水平以及临床参数和FT4.4指导管理.

关键词:

遗传性甲状腺功能低下症遗传性甲状腺功能低下症哈西莫托的甲状腺炎聚乙烯糖醇甲状腺刺激激素 (PEG-TSH) 的使用亚临床的甲状腺功能低下症.

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