出生月份是否会影响结肠直肠癌的预后?
José Martín-Arévalo1,2, David Moro-Valdezate3,4, Vicente Pla-Martí1,2
1Colorectal Surgery Unit, Department of General and Digestive Surgery, INCLIVA Biomedical Research Institute, Hospital Clínico Universitario de Valencia, University of Valencia, Av. Blasco Ibáñez, 17, 46010, Valencia, Spain.
Langenbeck's archives of surgery
|October 26, 2023
概括
在特定月份出生的结肠直肠癌患者的生存结果更好. 这项研究发现,CRC患者的出生月与整体生存期 (OS) 和无病生存期 (DFS) 之间存在关联.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 结肠直肠癌 (CRC) 是一个重要的全球健康问题.
- 了解结直肠癌的预后因素对于改善患者的治疗结果至关重要.
- 出生时间对癌症预后的潜在影响仍然是需要研究的领域.
研究的目的:
- 研究结直肠癌 (CRC) 患者出生月份与生存率之间的关联.
- 确定出生月份是否是CRC总生存期 (OS) 和无病生存期 (DFS) 的预后因素.
- 为了确定与不同瘤结果相关的特定出生月份.
主要方法:
- 在2005年至2019年期间接受手术的2520名成年CRC患者的观察研究.
- 利用K-means集群来按出生月份分组患者,并分析瘤结果.
- 用Kaplan-Meier和Cox回归分析进行生存评估,并进行模型稳定性的交叉验证.
主要成果:
- 三个不同的出生月份组表现出不同的瘤结果.
- 两组之间观察到总生存 (OS) (p<0.001) 和无病生存 (DFS) (p=0.03) 的显著差异.
- 出生月份集群被确定为OS和DFS的独立预后因素.
结论:
- 在出生月份和结直肠癌 (CRC) 患者的结果之间存在统计学上显著的关联.
- 1月,2月,6月,7月,10月和12月出生的患者表现出改善的OS和DFS.
- 这些发现表明出生月份可能是CRC管理中的新预后指标.
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