人类白细胞抗原基疗法的资格根据种族和种族
Timothée Olivier1,2, Alyson Haslam2, Jordan Tuia2
1Department of Oncology, Geneva University Hospital, Geneva, Switzerland.
JAMA network open
|October 26, 2023
概括
人类白细胞抗原 (HLA) 向疗法的临床试验显示了种族不平等. 非洲裔美国人最不可能有资格接受这些新型治疗方法.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
- 临床试验 临床试验
背景情况:
- 针对特定的人类白细胞抗原 (HLA) 亚型的新型治疗方法引起了人们对跨不同种族和民族群体平等获取的担忧.
- 了解资格差异对于制定包容性临床试验策略至关重要.
研究的目的:
- 调查在临床试验的资格方面的潜在种族和民族不平等,重点关注受HLA亚型限制的治疗方法.
主要方法:
- 在clinicaltrials.gov注册的临床试验截至2022年3月进行了横截面分析.
- 包括涉及具有特定HLA亚型限制的干预治疗方法的试验.
- 分析了基于种族和种族的资格概率.
主要成果:
- 在263个符合条件的试验中,估计获得资格的概率为50.3%.
- 非洲裔美国人的资格最低 (33.0%),而欧洲裔的资格最高 (53.0%).
- 抗癌疗法和治疗疫苗是最常见的试验类型,经常使用HLA-A*02:01和HLA-A2.2.
结论:
- 针对HLA的治疗试验的入学限制可能与种族和种族不平等有关.
- 解决这些差异对于确保获得创新医疗治疗的平等机会至关重要.
- 需要解决方案来克服生物挑战,并促进临床研究的包容性.
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