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增加循环中的microRNA-21水平作为预测事件脆弱性骨折风险更高的潜在指标

Zhen-Xing Si¹, Shi-Feng Zhou¹, Zi-Long Shen²

¹Department of Emergency Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Journal of osteopathic medicine

|October 26, 2023

概括

这项研究表明,高的microRNA-21 (miR-21) 水平与老年患者脆弱性骨折的风险增加有关. 循环中的miR-21在预测骨折风险方面具有诊断价值.

科学领域:

老年学是一门学科.
生物标志物生物标志物
整形外科整形外科整形外科

背景情况:

骨质疏松症是老年人普遍存在的疾病,显著增加骨折风险和死亡率.
目前的骨折风险评估工具存在局限性.
微RNA-21 (miR-21) 在骨质疏松症中的作用及其与骨折的关联仍然不清楚.

研究的目的:

调查血清miR-21水平与脆弱性骨折的存在之间的关联.
评估miR-21作为潜在的骨折风险生物标志物.

主要方法:

在200名患者中测量了血清miR-21水平.
在miR-21水平和骨折风险评估工具 (FRAX) 评分之间进行了相关性分析.
使用卡普兰-梅尔分析和考克斯回归来评估骨折发生率和风险因素.
用曲线下的面积 (AUC) 来确定miR-21的诊断值.

主要成果:

在miR-21水平和FRAX得分 (p<0.001) 之间发现了显著的关联.
患有较高miR-21水平的患者表现出明显更高的脆弱性骨折累积发病率 (p<0.001).
确定miR-21是骨折发病率的一个独立风险因素 (p=0.005).
在预测骨折时,miR-21的AUC为0.718.

结论:

血清miR-21在识别脆弱性骨折方面表现出最佳的诊断性能.
循环中的miR-21水平在预测脆弱性骨折风险方面具有潜在价值.

关键词:

循环生物标志物循环生物标志物骨折的风险,骨折的风险.骨折风险评估工具 (FRAX) 的使用这是一个微型RNA.骨质疏松症是一种骨质疏松症.

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