三甲基胺-N-氧化物与急性缺血性中风风险之间的关系:剂量反应元分析
Yuan Hong1, Zaidie Sun1, Nianqiu Liu2
1Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Yunnan Key Laboratory of Laboratory Medicine, Yunnan Province Clinical Research Center for Laboratory Medicine, Kunming, People's Republic of China.
PloS one
|October 26, 2023
概括
高水平的三甲基胺-N-氧化物 (TMAO) 与急性缺血性中风 (AIS) 的风险增加有关. 这一元分析证实了高TMAO和AIS之间存在显著的关联,突出了其作为风险因素的潜力.
科学领域:
- 生物化学 生物化学
- 心血管研究研究心血管研究
- 神经学 神经学
背景情况:
- 三甲基胺-N-氧化物 (TMAO) 与心血管疾病相关.
- TMAO与急性缺血性中风 (AIS) 之间的关联需要进一步调查.
研究的目的:
- 进行一项元分析,评估TMAO和AIS之间的关系.
- 评估与TMAO水平升高相关的AIS风险.
主要方法:
- 在多个数据库中进行了全面的文献搜索,截至2023年9月23日.
- 包括20项研究 (17个病例控制,3个队列) 与9141名参与者.
- 使用随机效应模型汇集数据并进行剂量反应分析.
主要成果:
- 与对照组相比,在AIS患者中观察到显著更高的血清/血TMAO度 (SMD = 1.27).
- 剂量反应分析表明,每增加1μmol/L的TMAO,AIS风险相对增加12.1% (RR = 1.12).
结论:
- 提升的TMAO水平与潜在的急性缺血性中风风险增加有关.
- TMAO可以作为AIS风险分层的重要生物标志物.
相关概念视频
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