相关实验视频

Updated: Jul 12, 2025

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Published on: June 16, 2022

可注射Zwitterionic物理水凝,具有增强化学动力学治疗和瘤微环境重塑特性,用于协同抗癌疗法

Yuelin Fang¹, Susu Huang¹, Qiaoying Hu¹

¹NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

|October 26, 2023

概括

这项研究引入了用于乳腺癌治疗的可注射水凝系统,该系统激活免疫系统并提供化疗,以防止手术后瘤复发. 这种方法增强了抗瘤免疫力,并向剩余的癌细胞.

科学领域:

生物材料科学生物材料科学
免疫治疗是一种免疫疗法.
在瘤学瘤学.

背景情况:

手术切除是乳腺癌的标准,但残留的瘤细胞和免疫抑制性瘤微环境 (TME) 会导致复发和转移.
水凝系统为手术后局部治疗提供了潜力,旨在改善结果.

研究的目的:

开发一种可注射的zwitterionic水凝系统,用于局部药物输送,免疫激活和预防手术切除后瘤复发.
将化学动力学疗法与STING通路激活相结合,以增强抗瘤免疫反应并消除剩余的癌细胞.

主要方法:

制造一种可注射的聚硫贝甲酸盐 (PSBMA) 水凝,具有较低的蛋白质吸附性和可调节的生物降解性.
将多克索鲁比辛 (DOX) 装入覆盖着巨细胞膜 (M/CuO2/DOX) 的过氧化铜纳米颗粒中,用于瘤向.
在PSBMA水凝 (Gel@M/CuO2/DOX/STING) 中同时加载M/CuO2/DOX和一个STING激动剂 (2',3'-cGAMP),用于联合治疗.

主要成果:

水凝系统成功释放了STING激动剂,激活了STING通路,并通过调节干扰素信号来重塑免疫抑制TME.
M/CuO2/DOX纳米粒子向剩余的瘤细胞,诱导DNA损伤,免疫细胞死亡和铜死亡.
结合疗法促进了树突细胞的成熟,增强了CD8+ T细胞的透,显著防止了术后瘤复发和转移.

结论:

开发的水凝系统有效地将化学动力学治疗与STING通路激活相结合,用于综合治疗残留乳腺癌.
这种方法显示了通过重塑TME和增强抗瘤免疫力来预防术后复发和转移的巨大潜力.

关键词:

癌症免疫疗法免疫疗法化学动力学疗法是一种化学动力学疗法.药物输送是药物输送的过程.术后治疗术后治疗这是一种zwitterionic水凝.

更多相关视频

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.