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相关概念视频

Brain Imaging01:14

Brain Imaging

235
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
235

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相关实验视频

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Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging
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通过跨直流刺激调节大脑功能的剂量反应:从局部到网络水平.

Ghazaleh Soleimani1, Rayus Kupliki2, Martin Paulus2

  • 1Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, United States of America.

PLoS computational biology
|October 26, 2023
PubMed
概括

这项研究探讨了跨直流刺激 (tDCS) 剂量与甲基胺使用障碍患者的大脑反应的关系. 网络级大脑连接与模拟电场剂量有显著的相关性.

科学领域:

  • 神经科学是一个神经科学.
  • 神经成像是一种神经成像.
  • 大脑刺激 大脑刺激

背景情况:

  • 了解剂量反应关系对于大脑刺激技术至关重要,比如横直流刺激 (tDCS).
  • 之前的研究集中在不同级别的分析,从神经元到网络尺度.
  • 计算建模和功能磁共振成像 (fMRI) 是量化刺激剂量和大脑反应的关键工具.

研究的目的:

  • 为了研究模拟电场和脑活动变化之间的剂量反应关系,在接受tDCS的甲基胺使用障碍 (MUDs) 患者中.
  • 通过多个分析层面来评估这种关系:voxel,区域,集群和网络.
  • 建立一个方法框架,在tDCS研究中将电场变化与神经反应联系起来.

主要方法:

  • 一个随机的,三重盲,假控制的试验,涉及60名参与者,MUDs接受tDCS.
  • 在tDCS之前和之后获取结构和功能MRI数据.
  • 生成单个头部模型来模拟电场,并对电场与fMRI衍生的脑活动变化之间的联系进行线性分析,这些变化在voxel,区域,集群和网络层面.

主要成果:

  • 在voxel,区域或集群级别的电场和功能活动变化之间没有发现FDR纠正的显著相关性.
  • 在网络层面上观察到,前极双面连接与前极极刺激部位的电场之间存在显著的正相关性 (r = 0.42,p = 0.02).

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  • 这表明网络级协会的效果大小为中等.

    • 结论:

    • 网络层面的分析对于理解tDCS神经调节效应对个体当前剂量的依赖性至关重要.
    • 拟议的管道为分析tDCS剂量反应关系提供了一个框架.
    • 整合剂量反应发现可以指导剂量优化和生物标志物发现在未来的大脑刺激研究.