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在药物升级后6个月内血管内超声波神经损伤或虚假手术的患者层面综合分析:RADIANCE临床试验计划

Michel Azizi^1,2,3, Andrew S P Sharp⁴, Naomi D L Fisher⁵

¹Université Paris Cité, France (M.A.).

|October 26, 2023

概括

与虚假手术相比,超声波缩有效降低高血压患者的长期血压,减少了额外的抗高血压治疗 (AHT) 的需要.

科学领域:

心血管医学
干预心脏病学
高血压管理

背景情况:

在RADIANCE- HTN SOLO,TRIO和II试验中,对高血压的超声波损伤 (uRDN) 进行了研究.
这些试验在手术后2个月实现了血压降低的主要终点.

研究的目的:

与假手术相比,评估RDN在6个月的有效性和安全性.
分析RDN对6个月的抗高血压治疗 (AHT) 的影响.

主要方法:

在三项随机对照试验中汇集了506名患者的个人数据.
轻度至中度或耐药高血压的患者随机分为URDN或假血压.
如果超过血压标准,则添加抗高血压治疗,结果在6个月后进行评估.

主要成果:

与假药组相比,URDN组的患者需要额外的抗高血压治疗 (AHT) 较少 (P=0. 004).
基线和药物调整后的6个月差异有利于日间门诊SBP (- 3.0 mm Hg),家庭SBP (- 5. 4 mm Hg) 和办公室SBP (- 5.2 mm Hg).
在RDN和假药组之间没有观察到安全结果的显著差异.

结论:

经过6个月的超声波缩显示持续降低血压的疗效.
在患有高血压的患者中,URDN减少了对额外的抗高血压药物的需求.
与假手术相比,该程序被发现是安全的,没有显著的不良事件.

关键词:

切除,导管抗高血压药物血液压力没有神经高血压高血压,脏疾病

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