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The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
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周产期缺氧缺血性脑病变:在现代美国出生队列中随时间的发生率
Marie-Coralie Cornet1, Michael Kuzniewicz2, Aaron Scheffler3
1Department of Pediatrics, University of California San Francisco, San Francisco, California.
Pediatric neurology
|October 26, 2023
概括
围产期缺氧缺血性脑病变 (HIE) 的发生率保持稳定. 诊断的增加和治疗性低温症的使用并没有反映出更高的疾病负担,突出了严格的诊断标准的需要.
科学领域:
- 新生儿医学 新生儿医学
- 围产期健康 围产期健康
- 神经学 神经学
背景情况:
- 研究表明,围产期缺氧缺血性脑病变 (HIE) 的发生率正在上升.
- 这可能是由于更好的检测和低温治疗,而不是发病率增加.
- 研究了美国人口中的HIE发病率趋势.
研究的目的:
- 为了确定随着时间的推移,围产期HIE的实际发病率.
- 为了区分疾病负担与诊断和治疗变化.
主要方法:
- 2012-2019年对289,793名婴儿 (怀孕≥35周) 的横截面研究.
- 使用新生儿酸性和脑病变标准定义了围产期HIE.
- 分析了HIE的医院出院诊断 (ICD代码).
主要成果:
- 周产期HIE的人口发病率为每1000例出生1.7例.
- HIE发病率保持稳定;诊断和低温治疗显著增加.
- 对于确诊的HIE,出院诊断敏感度 (72%) 和PPV (79%) 是中度的.
结论:
- 在研究期间,围产期HIE发病率稳定.
- 增加的HIE诊断和低温症使用并不意味着疾病的增加.
- 强调在HIE中需要严格的诊断标准.
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