传统上没有氨基酸丰富的皮肤病中的氨基酸
Isabella Sanchez1, Marina K Ibraheim2, Bonnie A Lee1
1Department of Dermatology, University of California Irvine, Irvine, CA.
The American Journal of dermatopathology
|October 26, 2023
概括
组织乙氨基,皮肤活检中乙氨基的存在,现在在以前认为缺乏它们的炎症性皮肤疾病中被发现. 这一发现挑战了皮病和皮肤肌炎等疾病的传统诊断标准.
科学领域:
- 皮肤病学 皮肤病学
- 病理学 病理学 病理学
- 免疫学 免疫学 免疫学
背景情况:
- 从历史上看,组织埃索诺菲利亚一直是某些炎症性皮肤疾病的关键诊断标志物.
- 最近的研究表明,在传统上不被认为富含乙氨基酸的疾病的皮肤活检中存在乙氨基酸.
- 越来越多的情况,如皮肤肌炎 (DM),牛皮和状硬化 (LS) 越来越多地被认为是eosinophils的港口.
研究的目的:
- 在皮肤病的皮肤活检中系统地审查现有关于组织菌素的文献.
- 为了研究在传统上被认为是eosinophil-poor的炎症性皮肤疾病中的eosinophils的患病率.
主要方法:
- 系统的文献审查.
- 分析了26项已识别的研究,主要是回顾性审查.
- 汇编了在各种皮肤病中报告的乙酸氨基基存在的百分比.
主要成果:
- 报告显示,在几种"低乙烯基氨基酸"皮肤病中,存在高乙烯基氨基酸的显著百分比.
- 牛皮:18%-73%的人患有牛皮
- 皮皮里亚斯风疹 (Pityriasis rubra pilaris,简称PRP):22%至63%左右的情况.
- 状硬化 (LS):29%-53% - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- 皮肤肌肉炎 (DM):15%至44%
- 莫菲亚:8%至45%之间
- 过度化的平坦 (LP): 0%-21%
- 口服LP:0%-4% 在口服中使用.
结论:
- 在所谓的低乙素皮肤病症中存在组织乙素的存在可能是一个诊断陷.
- 组织异osinophilia 不应该是唯一的因素用于排除诊断,如牛皮,DM,或LS.
- 可能需要重新评估炎症性皮肤疾病的诊断标准.
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