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巨 lncRNAs 在癌症发育: 期待已久的治疗点

Imene Arab¹, Jeongkwang Park¹, Jae-Joon Shin¹

¹School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Republic of Korea.

Biochemical pharmacology

|October 26, 2023

概括

长非编码RNAs (lncRNAs) 在塑造瘤微环境相互作用方面发挥着至关重要的作用,特别是影响巨细胞两极分化. 针对这些巨关联的lncRNAs为癌症治疗提供了一个有前途的治疗策略.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

瘤微环境涉及巨细胞,癌细胞和内皮细胞之间的复杂相互作用.
与瘤相关的巨细胞 (TAMs),通常是M2极化,促进瘤生长和血管生成.
长非编码RNAs (lncRNAs) 越来越多地被认为是它们在调节巨细胞功能和癌症发展中的作用.

研究的目的:

审查目前对癌症中巨细胞相关 lncRNAs 的理解.
强调这些lncRNAs在癌症进展中的分子标和调控作用.
探索针对癌症相关 lncRNAs 的治疗策略.

主要方法:

文献综述综合了现有关于巨 lncRNAs 癌症的研究.
对lncRNA参与巨细胞极化 (M2/TAM主导) 的分析.
检查细胞间外体/细胞外囊介导的 lncRNA 转移.

主要成果:

巨关联的lncRNAs显著影响巨偏向M2/TAM表型的巨偏向.
lncRNAs通过外体细胞在巨细胞和癌细胞之间转移,改变细胞功能.
在动物模型中 lncRNA 操纵显示了减少疾病严重性的治疗潜力.

结论:

巨关联的lncRNAs是瘤微环境和癌症进展的关键调节者.
准这些lncRNAs,包括它们的细胞间传输,是一个可行的治疗途径.
对巨 lncRNAs的进一步研究可以为新型抗癌治疗的开发提供信息.

关键词:

癌症癌症癌症癌症异构体是什么? 异构体是什么? 外构体是什么?在M2巨细胞中.巨细胞的两极分化这就是TAMAMTAM.治疗目标治疗目标在ncRNA中,我们可以

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