热液晶相:药物输送和生物医学应用
Vivek P Chavda1, Sathish Dyawanapelly2, Shilpa Dawre3
1Department of Pharmaceutics and Pharmaceutical Technology, L M College of Pharmacy, Ahmedabad 380009, India; Department of Pharmaceutics & Pharm. Technology, K. B. Institute of Pharmaceutical Education and Research, Kadi Sarva Vishwavidyalaya, Gandhinagar 382023, Gujarat, India.
International journal of pharmaceutics
|October 26, 2023
概括
液晶 (LC) 纳米配方提供先进的药物输送. 热液晶相 (LLCPs) 显示出药物,蛋白质和疫苗的有针对性输送的前景.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 随机液晶相 (LLCP) 由于其独特的结构性质,正在引起药物输送的兴趣.
- 液体和固体的特性结合在一起,使有效的药物加载,稳定和受控释放成为可能.
- 它们与生物膜的结构相似性增强了生物粘合性和生物相容性,用于有针对性的输送.
研究的目的:
- 总结基于液晶 (LC) 的纳米配方,特别是LLCP的工程方面.
- 审查LC在各种药物输送途径中的应用,包括亲肠道,口腔和透皮.
- 讨论LC在医学成像和先进的疫苗/生物医学应用中的潜力.
主要方法:
- 通过两性脂质,水和稳定剂的同质化形成LLCPs.
- 不同的中相的特征,如双连续立方体 (立方体) 和反向六角形 (六角体).
- 对基于LC的药物输送系统及其应用现有文献的审查.
主要成果:
- 简单的临床治疗方案 (LLCP) 显示出改善药物加载,稳定和控制释放治疗药物的潜力.
- 液结体表现出增强的生物粘合性和生物相容性,使其适合于向药物输送.
- 不同的输送路径和应用,包括门,口腔,透皮和医学成像,都是可行的LC系统.
结论:
- 基于液晶的纳米配方,特别是LLCP,是下一代药物输送系统的一个有前途的平台.
- 对LC的工程和应用的进一步研究可以导致更有效的向疗法和生物医学应用.
- 液晶连接器具有多功能,可以提供广泛的治疗药物,包括药物,蛋白质,和疫苗.
相关概念视频
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
314
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
314
Drug Delivery: Overview
300
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
300
Drug Administration and Therapy Phases: Overview
486
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
486
Biopharmaceutics and Pharmacokinetics: Overview
2.1K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
2.1K
Drug Delivery: Miscellaneous Routes
359
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
359


