塔拉罗米切斯马尔内菲伊 (Talaromyces marneffeii) 躲避宿主天生的免疫防御的能力的演化
Zehan Zhang1, Beiping Li1, Zili Chai1
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, 100071, China.
International journal of biological macromolecules
|October 26, 2023
概括
Talaromyces marneffei通过其 Mp1p 蛋白质逃避免疫系统,这可能是由于横向基因转移和基因重复引起的. 这项研究还引入了一种用于识别Talaromyces物种的新方法.
科学领域:
- 菌类学 菌类学是指菌类学.
- 进化生物学 进化生物学
- 免疫学 免疫学 免疫学
背景情况:
- 塔拉罗米塞斯 (Penicillium) marneffei是一种细胞内致病性真菌,在免疫性受损的个体中引起菌.
- Mp1p蛋白是一种关键的毒性因子,使T. marneffei能够逃避宿主免疫反应.
- 了解新功能的演变,如免疫逃避,在生物学中至关重要.
研究的目的:
- 调查T. marneffei中病毒性因子Mp1p背后的进化起源和机制.
- 探索横向基因转移 (HGT) 和基因重复在T. marneffei免疫逃避策略的进化中的作用.
- 开发一种改进的方法来准确识别Talaromyces物种.
主要方法:
- 在真菌物种中对 Mp1p 同类物种进行了家族遗传学分析和序列相似性搜索.
- 对 Mp1p 域的分类学分布和进化关系的分析.
- 开发和应用一种用于识别Talaromyces菌株的新方法.
主要成果:
- 在T. marneffei中,Mp1p-LBDs的祖先是通过水平基因转移 (HGT) 获得的.
- 在T. marneffei中观察到广泛的基因重复和涉及Mp1p同类的潜在基因融合事件.
- 提出了一种新的识别方法,揭示了4个Talaromyces菌株的错误分类.
结论:
- 在T. marneffei的Mp1p进化是由HGT和基因重复的特征,促进免疫逃脱.
- 这些进化机制是了解T. marneffei如何逃避宿主天生的免疫力的关键.
- 这项研究为Talaromyces的识别提供了一种精细的方法,纠正了以前的错误分类.
相关概念视频
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Transduction
21
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
21
Cell-mediated Immune Responses
68.6K
Overview
68.6K
Defenses Against Pathogens and Herbivores
23.8K
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
23.8K
Defense Mechanism Against Infection
6.5K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
6.5K
Cells of the Innate Immune Response
1.7K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.7K


