放射基因组学为表现为单臂1p或19q删除的结质瘤提供了洞察力
Arian Lasocki1,2,3, Michael E Buckland4,5, Tahlia Molinaro6
1From the Department of Cancer Imaging (A.L.), Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia arian.lasocki@petermac.org.
AJNR. American journal of neuroradiology
|October 26, 2023
概括
具有单一1p或19q删除 (无删除) 的IDH突变质瘤显示的成像和存活模式与星系细胞瘤相似,而不是寡干质瘤. 这有助于区分这些脑瘤类型.
科学领域:
- 神经瘤学神经瘤学
- 分子诊断学 分子诊断学
- 放射学 放射学是一门学科.
背景情况:
- IDH突变性质瘤根据1p/19q状态进行分类:有线切除 (类质瘤) 或无线切除 (类细胞瘤).
- 单臂1p或19q删除 (无删除) 被诊断为星细胞瘤,但可能代表未分类的代码删除瘤.
- 这项研究调查了未删除质瘤的成像和生存特征.
研究的目的:
- 为了确定未被删除的IDH突变质瘤是否表现出MR成像特征,患者的存活率是否与星球细胞瘤或寡类质瘤一致.
- 评估T2-FLAIR不匹配标志和化作为潜在的差异化标志.
- 为了比较未删除,共删除和未删除质瘤之间的结果.
主要方法:
- 对已知1p/19q状态的121个IDH突变2-3级质瘤进行了回顾性分析.
- 两个神经放射学家评估了MRI成像对T2-FLAIR不匹配标志和化的评估.
- 在不同的1p/19q删除组中比较成像特征和患者存活率.
主要成果:
- 未被删除的瘤 (12) 显示T2-FLAIR不匹配标志更频繁 (33%) 比被删除的瘤 (0%),类似于未被删除的瘤 (49%).
- 在未切除的瘤 (0%) 与已切除的瘤 (25%) 相比,形较少.
- 未删除瘤的中位生存期 (7.8年) 与未删除瘤 (8.5年) 相似,但明显短于已删除瘤 (未达到>12年).
结论:
- IDH-突变结质瘤与无删除显示MRI成像特征和生存结果与星球细胞瘤一致.
- 这些发现区分了未切除的质瘤与1p/19q-codeleted oligodendrogliomas.
- 无缺失状态是对IDH突变质瘤的分类和预测结果的一个重要因素.
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