GC偏差基因转换驱动了哺乳动物和鸟类基因组中超保守元素的加速进化
Anguo Liu1,2, Nini Wang1,3, Guoxiang Xie1,2
1Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Genome research
|October 26, 2023
概括
超保存元素 (UCE) 是关键的基因组区域. GC偏差基因转换 (gBGC) 推动了快速的UCE进化,影响了物种间的适应性进化.
科学领域:
- 基因组学就是基因组学.
- 进化生物学 进化生物学
- 分子生物学分子生物学
背景情况:
- 超保存元素 (UCE) 是物种中高度保存的基因组区域,据推测具有关键功能.
- 一些UCE在特定血统中的快速进化引发了关于它们在适应性进化中的作用的问题.
研究的目的:
- 使用扩展的基因组数据集识别和分析哺乳动物和鸟类UCE.
- 调查UCE的功能约束和进化动态,特别是那些表现出加速进化的UCE.
- 探索GC偏差基因转换 (gBGC) 在UCEs的谱系特异性进化中的作用.
主要方法:
- 对95种哺乳动物和94种鸟类基因组进行比较基因组学分析,以确定UCE.
- 功能丰富分析以了解UCEs的生物作用.
- 鉴定和分析特定于血统的加速UCE演变,重点是gBGC.
主要成果:
- 确定了2191种哺乳动物和5938种鸟类的UCE,证实了它们的功能约束和与广泛表达的基因的关联.
- 在经过测试的哺乳动物和鸟类血统中,在0.19%13.2%的UCE中观察到血统特定的加速进化.
- 发现高达62.1%的快速进化的UCE可能受到gBGC的影响,包括改变神经基因表达的鹿类特定区域.
结论:
- 基因偏差转换 (gBGC) 显著促进了UCE的加速演变.
- 即使在高度保守的调节元素中,gBGC和选择之间的相互作用也会塑造进化模式.
- 这些发现支持了多种进化力量在塑造适应性进化中的作用,包括在UCE中.
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