和多基物质 (PFAS) 暴露和甲状腺癌风险
Maaike van Gerwen1, Elena Colicino2, Haibin Guan3
1Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
暴露于per-和多醇基物质 (PFAS) 与更高的甲状腺癌发病率有关. 这项研究发现线性 perfluorooctanesulfonic 酸 (n-PFOS) 与增加甲状腺癌风险之间存在显著联系.
科学领域:
- 环境健康 环境健康
- 在瘤学瘤学.
- 毒理学 毒理学 毒理学
背景情况:
- 人们越来越担心甲状腺癌趋势的增加.
- 对和多基物质 (PFAS) 和甲状腺癌的人类研究有限.
- PFAS是广泛存在的环境污染物.
研究的目的:
- 研究血PFAS水平与甲状腺癌诊断之间的关联.
- 评估特定的PFAS化合物作为甲状腺癌的潜在风险因素.
- 使用嵌套的病例控制研究设计进行可靠的分析.
主要方法:
- 在BioMe生物库内进行了嵌套病例控制研究.
- 88名甲状腺癌患者和88名匹配的健康对照.
- 使用液体染色学高分辨率质谱测量血PFAS水平.
- 使用无条件逻辑回归来确定赔率比率 (ORadj) 和置信区间 (CI).
主要成果:
- 线性 perfluorooctanesulfonic 酸 (n-PFOS) 的每倍增加的甲状腺癌发生率增加了 56% (ORadj: 1.56, 95% CI: 1.17-2.15).
- 仅分析乳头甲状腺癌病例时,结果一致.
- 在考虑诊断前暴露时间的分析中,积极的关联仍然存在.
结论:
- 这项研究提供了证据,证明PFAS暴露与甲状腺癌发病率增加之间存在关联.
- 由于广泛的污染,PFAS暴露给全球健康带来了担忧.
- 需要进一步进行大规模的前性研究,以调查更广泛的PFAS化学品.
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