相关实验视频
Updated: Jul 12, 2025

08:02
In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
5.5K
口服免疫疗法通过代谢重编程重塑肠道免疫抑制以增强全身抗瘤免疫力
Xinran Cao1,2, Yuan Xu1,2, Chen Zhou1,2
1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|October 26, 2023
概括
这项研究引入了免疫增强富勒 (IEF) 作为口服免疫疗法,以增强抗瘤免疫力. IEF重编程肠道免疫细胞,增强全身免疫力,并安全有效地将冷瘤转化为热瘤.
科学领域:
- 免疫学 免疫学 免疫学
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 癌症免疫疗法面临着有效性和副作用有限的挑战.
- 肠道免疫系统影响全身免疫力,但很难对抗瘤效应进行操纵.
研究的目的:
- 开发一种使用免疫增强富勒伦 (IEF) 的口服免疫疗法策略.
- 调查IEF重新编程肠道免疫细胞以增强全身抗瘤免疫的能力.
主要方法:
- 使用免疫增强富勒伦 (IEF) 进行口服免疫治疗.
- 研究IEF对肠道免疫细胞中的巨分化和能量代谢的影响.
- 在体内评估了全身抗瘤免疫力和瘤微环境的变化.
主要成果:
- IEF成功地将抗炎性巨细胞改造为杀伤瘤的巨细胞.
- 在肠道免疫细胞中,调节了从氧化酸化到糖解的能量代谢.
- 重新编程免疫抑制性肠道环境,增强全身免疫力,并将"冷"瘤转化为"热"瘤.
结论:
- 使用IEF的口服免疫疗法为癌症治疗提供了安全有效的策略.
- 通过调节肠道免疫细胞和代谢途径,IEF可以重振抗瘤免疫力.
- 这种方法有望改善癌症免疫治疗结果.
相关概念视频
Tumor Immunotherapy
538
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
538
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
170
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
170
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
338
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
338

