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甲状腺变化和易受免疫检查点抑制剂心肌炎的影响
Charlotte Fenioux1,2, Baptiste Abbar1,3, Samia Boussouar4
1Sorbonne Université, INSERM, CIC-1901 Paris-Est, Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Department of Pharmacology, Paris, France.
Nature medicine
|October 26, 2023
概括
免疫检查点抑制剂 (ICI) 可以引起严重的自身免疫副作用. 胸膜变化,特别是胸膜瘤,与这些ICI诱导的肌肉毒性更高的风险和严重程度有关.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗,但可以引发罕见的,严重的自身免疫反应,如心肌炎和肌肉炎.
- 胸腺对于T细胞发育和免疫耐受性至关重要.
结论:
- 胸膜变化与免疫检查点抑制剂诱导的肌肉毒性发生和严重程度有显著的关联.
- 通过临床,放射学和生物评估来评估胸腺,可能有助于预测和管理ICI相关的自身免疫毒性.
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