食品粘度对药物溶解的影响
Rika Hirose1, Kiyohiko Sugano2
1Molecular Pharmaceutics Lab., College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1, Noji-Higashi, Kusatsu, Shiga, 525-8577, Japan.
食品粘度对药物溶解率的影响很小,FDA早餐均主要影响的是宏观粘度,而不是微观粘度. 这表明食物粘度对药物吸收的影响有限.
科学领域:
- 药品制造 药品制造 药品制造
- 物理化学 物理化学
- 食品科学 食品科学 食品科学
背景情况:
- 食品粘度通过宏观粘度和微观粘度影响药物溶解速度.
- 宏观度会影响扩散层厚度,而微观度会影响分子扩散.
- 在内在溶解速率 (IDR) 中的质量转移系数 (kc) 是粘度依赖的 (kc ηa).
研究的目的:
- 为了研究食物粘度对药物溶解的影响.
- 区分宏观粘度和微观粘度对药物溶解的影响.
- 为了确定指数"a",将质量转移系数与粘度相关.
主要方法:
- 可因被用作一种模型药物.
- 使用了基烯纤维素 (HPC),甲基纤维素 (MC) 和糖等加厚剂.
- 准备和稀释了FDA早餐均剂 (BFH);IDR通过对盘方法测量.
主要成果:
- BFH显著增加粘度 (209 mPa·s),HCl进一步增加,但素减少.
- BFH对kc (a ≈ -0.00到 -0.09) 的影响很小,类似于HPC (a ≈ -0.19) 和MC (a ≈ -0.21).
- 糖显著降低了kc (a ≈ -0.70),表明对宏观和微观粘度都有影响.
结论:
- 美国食品和药物管理局的早餐均主要增加了宏观粘度,对药物溶解的影响很小.
- 观察到的BFH粘度变化并没有显著改变本佐卡因的内在溶解率.
- 研究结果表明,食品粘度对药物溶解的影响主要是通过宏观粘度变化.
更多相关视频
10:10Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
09:59Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution
Published on: July 4, 2014
相关概念视频
Factors Influencing Drug Absorption: Drug Dissolution
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Theories of Dissolution: Diffusion Layer Model
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
