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化合物治疗肺癌多药耐药性细菌感染的治疗方法在体外模型中

Demet Celebı^1,2, Ozgur Celebı³, Elif Aydin⁴

¹Department of Microbiology, Faculty of Veterinary Medicine, Ataturk University, 25240, Erzurum, Turkey. celebiidil@atauni.edu.tr.

Biological trace element research

|October 26, 2023

概括

化合物显示出有希望的抗微生物和抗菌膜活性对抗多药耐药细菌,包括Acinetobacter baumannii,Klebsiella pneumoniae和Pseudomonas aeruginosa. 这些化合物还表现出抗癌作用,降低了肺癌细胞的活力.

科学领域:

微生物学微生物学
在瘤学瘤学.
材料科学材料科学材料科学

背景情况:

耐多药细菌对全球健康构成重大威胁.
感染使癌症治疗复杂化,特别是在接受化疗或类固醇治疗的肺癌患者中.
对于抗药性感染和它们对癌症结果的影响来说,急需新型治疗剂.

研究的目的:

研究化合物的抗微生物,抗菌膜和抗癌性质.
评估化合物对常见肺癌病原体的疗效.
评估化合物对癌细胞活力和氧化应激的影响.

主要方法:

检查板方法来确定化合物和抗生素的分数抑制度 (FIC) 指数.
在A549肺癌细胞系中感染了Acinetobacter baumannii,Klebsiella pneumoniae和Pseudomonas aeruginosa.
细胞活力测试 (MTT),抗氧化能力,总氧化剂状态,以及对8-OHdG表达的免疫光.

主要成果:

化合物显示出显著的抗菌膜活性,平均为A. baumannii的46%,P. aeruginosa的45%,K. pneumoniae的43%.
在癌细胞培养物中,化合物降低了细胞活力和抗氧化能力,同时增加了总氧化剂状态.
免疫光检测显示,化合物增加了8-OHdG的表达,与MTT测定结果相关.

结论:

化合物表现出有希望的抗微生物和抗菌膜作用,特别是在对抗多药耐药细菌菌株时.
这项研究表明化合物的潜在抗癌活性,影响癌细胞活力和氧化应激标志物.
化合物代表了一种潜在的治疗途径,用于治疗癌症患者的感染,并对抗抗生素耐药性.

关键词:

具有抗菌活性,具有抗菌活性.化合物化合物化合物耐药性肺癌耐药性肺癌标签: 毒品标签: 毒品毒品甲单水化合物甲单水化合物甲酸酸是一种

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