减轻缺氧可以改善癌症免疫疗法
Peng Fan1,2, Naidong Zhang2, Eleonora Candi1
1Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy.
Oncogene
|October 26, 2023
概括
瘤缺氧阻碍了癌症免疫治疗. 血管正常化策略可以逆转缺氧,增强免疫细胞功能,并提高免疫疗法的有效性,以获得更好的患者结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 血管生物学 血管生物学
背景情况:
- 瘤缺氧,由异常的瘤血管造成,创造了一个免疫抑制性瘤微环境 (TME).
- 缺氧促进血管生成,代谢重编程,细胞外矩阵重塑,上皮-介质细胞过渡 (EMT),p53无活化和免疫逃避,阻碍免疫疗法.
- 功能失调的瘤血管是有效的癌症免疫治疗的主要障碍.
研究的目的:
- 审查瘤缺氧的机制及其对癌症免疫疗法的影响.
- 讨论诱导瘤血管正常化的策略.
- 总结支持结合癌症免疫疗法的血管正常化证据.
主要方法:
- 关于瘤缺氧机制的文献综述.
- 对血管正常化策略的分析.
- 对联合血管正常化和免疫治疗的数据的综合.
主要成果:
- 血管正常化改善了氧气输送,并逆转了缺氧引起的免疫抑制.
- 恢复了血管功能,增强了抗瘤免疫反应.
- 有证据支持将血管正常化与免疫疗法结合起来,以克服缺氧诱导的抗性.
结论:
- 通过血管正常化向瘤缺氧是一种有前途的策略,可以提高癌症免疫治疗的疗效.
- 血管正常化可以改善接受免疫治疗的癌症患者的临床结果.
- 需要进一步研究和临床应用血管正常化与免疫疗法结合的方法.
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