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一种可注射和可生物降解的zwitterionic凝,用于延长胰岛素输液导管的寿命和性能

Ershuai Zhang¹, Yuanjie Shi¹, Xiangfei Han¹

¹Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, USA.

Nature biomedical engineering

|October 26, 2023

概括

一种新的生物降解凝通过减少皮肤刺激和增强胰岛素吸收来改善连续皮下胰岛素输注 (CSII) 治疗. 这一创新延长了导管的寿命,有利于动物模型中的糖尿病管理.

科学领域:

生物材料科学生物材料科学
内分泌学在内分泌学.
医疗器械医疗器械

背景情况:

持续的皮下胰岛素输注 (CSII) 对于糖尿病管理至关重要,但受到皮肤并发症和胰岛素吸收受损的限制.
由于这些问题,目前的CSII导管使用需要频繁地址旋转.

研究的目的:

开发和评估一种可生物降解的zwitterionic凝,以改善CSII导管的寿命和胰岛素吸收.
评估凝对皮肤刺激和局部组织反应的影响.

主要方法:

在商用CSII导管的尖端涂上一种可生物降解的zwitterionic凝.
修改后的导管植入糖尿病小鼠超过6个月,糖尿病小猪长达13天.
监测胰岛素吸收率和局部组织反应.

主要成果:

该凝完全消除了早期皮肤刺激,并在小鼠和小猪中延长了导管寿命.
与标准CSII和常规注射相比,观察到显著改善的胰岛素吸收率.
凝表现出抗炎和抗异体反应的特性,促进新血管化.

结论:

可生物降解的zwiterionic凝是克服CSII限制的有希望的解决方案.
这项技术提高了胰岛素的输送和患者的舒适性,并有可能用于其他可植入装置.

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