狗的扩散性大b细胞淋巴瘤通过瘤衍生的细胞外囊泡降低CD8+T细胞的活性
Hsin-Pei Weng1, Chiao-Hsu Ke1, Chun-Wei Tung2,3,4
1Department of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, No.1 Sec.4 Roosevelt Rd, Taipei, 10617, Taiwan ROC.
Cancer cell international
|October 26, 2023
概括
瘤衍生的细胞外囊泡 (EVs) 来自犬类淋巴瘤诱导CD8+T细胞亡并促进调节性T细胞表型. 这会损害抗瘤免疫力,这表明EV阻塞是淋巴瘤的潜在治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞外囊泡生物学 细胞外囊泡生物学
背景情况:
- 瘤衍生的细胞外囊泡 (EVs) 调解免疫相互作用,这对癌症的发展,进展和转移至关重要.
- 狗淋巴瘤是一种常见的恶性瘤,需要有效的T细胞反应来控制,但与CD8+T细胞的免疫交叉对应尚不清楚.
研究的目的:
- 研究来自犬B细胞淋巴瘤的细胞外囊泡 (EVs) 对CD8+T细胞的免疫调节作用.
- 探索针对这些EV作为治疗犬淋巴瘤的治疗策略的潜力.
主要方法:
- 从狗B细胞淋巴瘤细胞系和临床样本中分离和描述EVs.
- 狗的CD8+T细胞与淋巴瘤衍生的EVs的共同培养.
- 对T细胞亡,表型 (CTLA-4,PD-1,PD-L1,FoxP3表达) 和细胞因子分泌的分析.
主要成果:
- 淋巴瘤衍生的EVs在CD8+T细胞中诱导了亡.
- EVs在CD8+T细胞中的CTLA-4,PD-1,PD-L1和FoxP3mRNA上调,促进了一个调节性表型.
- 这些调控性CD8+T细胞分泌抑制性细胞因子和血管原因子,创造了一个亲瘤的微环境.
结论:
- 狗B细胞淋巴瘤衍生的EV抑制抗瘤CD8+T细胞活性.
- EVs操纵CD8+T细胞向一个调节性表型,阻碍宿主细胞免疫力.
- EV阻塞通过恢复抗瘤T细胞功能,为淋巴瘤提供了一个有希望的治疗途径.
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