身体表现在一个多样化的,基于人群的系统性狼 erythematosus 的个人队列
Laura C Plantinga1, C Barrett Bowling2, Courtney Hoge3
1University of California, San Francisco.
Arthritis care & research
|October 27, 2023
概括
超过一半的系统性红斑狼 (SLE) 患者体验身体表现不佳. 诸如较高的BMI,疾病活动和抑郁症状等因素与更糟糕的结果有关,而就业和认知功能则具有保护作用.
科学领域:
- 类风湿病学 类风湿病学
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,影响多个器官系统.
- 身体表现是健康和功能状态的关键指标,特别是在慢性疾病中.
- 了解影响SLE身体表现的因素对于患者的管理和改善生活质量至关重要.
研究的目的:
- 确定SLE患者的不同队列中体力表现不佳的患病率和相关因素.
- 确定SLE患者体力功能下降的临床,人口和心理相关性.
主要方法:
- 研究了一组基于人口的446名在亚特兰大大都会地区患有SLE的人群.
- 使用短物理性能电池 (SPPB) 评估体力表现,分数从0-12不等.
- 多变量逻辑回归分析了SPPB分数 (中低[<10]与高[≥10]) 和各种患者特征之间的关联.
主要成果:
- 近60%的参与者表现出中低的体力表现.
- 身体下部力量尤其受到影响,只有7%的人达到最高分数.
- 较高的体重指数,SLE疾病活动和负担以及抑郁症状与较差的身体表现有关.
- 当前就业和更高的认知功能与更好的身体表现有关.
结论:
- 身体表现不佳在患有SLE的个体中非常普遍.
- 无论是SLE特异性 (疾病活动,负担) 和非SLE特异性因素 (BMI,就业,认知,心理健康) 都会导致身体表现缺陷.
- 识别有风险的个体可以进行有针对性的干预,以改善,维护和支持SLE人口的身体功能.
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