莱沃甲氧氨酸软凝囊在服用质子抑制剂的甲状腺切除患者中的有效性:一项开放性研究

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Issac Sachmechi¹, Kathryn Jean Lucas², Larry D Stonesifer³

¹Mount Sinai Services-NYC Health+Hospitals/Queens, Jamaica, New York, USA.

Thyroid : official journal of the American Thyroid Association

|October 27, 2023

概括

在服用质子抑制剂 (PPI) 的患者中,切换为levothyroxine sodium (LT4) 软囊可能会改善甲状腺激素的吸收. 这项研究发现,在从LT4片切换到软囊后,TSH降低和甲状腺激素水平增加.

科学领域:

内分泌学在内分泌学.
药理动力学药理动力学

背景情况:

质子抑制剂 (PPI) 和抗酸药可以干扰甲 (LT4) 片的胃肠道吸收.
接受LT4治疗的甲状腺功能低下症患者在与PPI或抗酸药同时使用时需要监测.

研究的目的:

评估一下软凝囊配方的LT4 (Tirosint®) 是否能够克服PPI引起的吸收干扰.
评估从传统的LT4药片转换为LT4软囊在PPI的甲状腺功能下降患者的影响.

主要方法:

经过甲状腺切除术治疗稳定的LT4片剂治疗和PPI的患者被转换为12周的同等剂量的LT4软囊.
血清甲状腺激素 (TSH) 水平是主要终点;二级终点包括自由和总甲状腺素 (fT4,TT4),自由和总三甲状腺素 (fT3,TT3),肌酸酸酶 (CPK) 和脂质面板水平.

主要成果:

在转换为LT4软囊后的第6周和第12周观察到平均TSH水平的统计学上显著下降.
同时观察到血清中自由三甲氨酸 (fT3) 和总三甲氨酸 (TT3) 水平的统计显著增加.
还观察到血清低密度脂蛋白,总胆固醇和CPK水平的显著降低.

结论:

在接受PPI的甲状腺切除术的患者中,从LT4片切换为LT4软囊与改善的LT4吸收有关,由降低TSH和增加甲状腺激素水平表明.
与传统药片相比,LT4的软囊配方可能不太容易受到PPI的吸收干扰.

关键词:

泰罗辛特泰罗辛特是什么意思抗酸剂是一种抗酸药.囊中的囊.甲状腺功能低下症甲状腺功能低下症甲氧氨酸 (Levothyroxine) 是一种抗氧化剂.质子抑制剂的使用

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