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对乌罗莫杜林聚合物的基效应驱动自体主导的管间性病

Guglielmo Schiano1, Jennifer Lake1, Marta Mariniello1

  • 1Mechanisms of Inherited Kidney Disorders, Institute of Physiology, University of Zurich, Zurich, Switzerland.

EMBO molecular medicine
|October 27, 2023
PubMed
概括

尿素 (UMOD) 基因中的错误突变会导致自身主导的管间性病 (ADTKD). 有毒的乌罗莫杜林聚合物驱动ADTKD的进展,建议针对聚合物清除的治疗策略.

关键词:
这就是ADTKD-UMOD.聚合物 聚合物 聚合物功能获取 - 功能获取脏纤维化 脏纤维化不折叠的蛋白质反应反应

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