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便携式双通道血液酶分析仪用于医疗中心肝功能检测

Jingwei Sang¹, Jie Cheng², Honghua Hu³

¹University of Electronic Science and Technology of China, Chengdu 611731, China.

|October 27, 2023

概括

一种新的便携式血液酶分析仪 (BEA) 能够快速,同时检测肝功能关键指标氨酸转移酶 (ALT) 和酸氨酸转移酶 (AST) 在护理点. 该设备提供与临床分析仪相比较准确的结果,促进远程诊断和疾病管理.

科学领域:

生物医学工程生物医学工程
临床诊断临床诊断临床诊断
医疗器械医疗器械

背景情况:

由于肝脏的中心代谢作用,慢性肝病的准确诊断至关重要.
氨酸氨基转移酶 (ALT) 和酸氨基转移酶 (AST) 是肝功能重要指标.
目前的同时检测方法需要复杂的设备和程序,限制了医疗点的应用.

研究的目的:

开发一款便携式的双通道血液酶分析仪 (BEA),用于对ALT和AST的临床检测.
为了使这些肝酶的同时和准确量化.
为了促进远程诊断和个人疾病管理.

主要方法:

一个便携式双通道血液酶分析仪 (BEA) 是使用光度反射设计的.
该装置精确地保持测试温度在37°C ± 0.1°C.
该BEA的性能使用当地医院的血液样本进行了验证,并与罗氏科巴斯C702分析仪进行了比较.

主要成果:

BEA实现了低检测极限 (ALT为3.5 U L−1,AST为4 U L−1) 和临床相关的检测范围.
变化系数 (CV) 在ALT和AST均低于10%.
与临床分析仪相比,观察到高的线性相关系数 (ALT为0.9827,AST为0.9714).
智能手机连接使远程数据分析和存储成为可能.

结论:

便携式BEA可在护理地点准确并同时检测ALT和AST.
该设备表现出高精度和可靠性,与复杂的临床分析仪相当.
BEA显示了远程诊断,预防性医疗保健和整合到医疗物联网的巨大潜力.

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