动脉样硬化与原发性Sjogren综合征之间的关联:一个横截面研究
Shuang Liu1, Xingjun Li1, Qian Yang2
1Department of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical University Kunming China.
Health science reports
|October 27, 2023
概括
动脉样硬化影响41.3%的原发性Sjogren综合征患者,疾病持续时间,B细胞,T辅助细胞和CRP是关键的危险因素. 免疫球蛋白M可以提供保护,而标准疗法没有预防作用.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 心血管医学 心血管医学
背景情况:
- 系统性自身免疫性疾病与增加动脉样硬化 (AS) 风险有关.
- 主要Sjogren综合征 (pSS) 和AS之间的特定关联和机制尚不清楚.
- 了解这种联系对于管理PSS患者的心血管健康至关重要.
研究的目的:
- 确定pSS患者中AS的流行率.
- 在这个人群中确定与AS相关的风险因素.
- 探索免疫细胞和炎症性细胞因子在与pSS相关的AS中的作用.
主要方法:
- 一项涉及155名pSS患者的横截面研究.
- 数据收集包括人口统计,AS事件,免疫细胞计数,炎症性细胞因子水平和临床数据.
- 使用SPSS v20.0.0.进行了统计分析,包括相关性分析.
主要成果:
- 在pSS患者中AS事件的患病率为41.3%.
- 冠状动脉内心介质厚度与IgA正相关,与IgM负相关.
- 脚-手臂脉冲波速率 (baPWV) 与疾病持续时间,B细胞,T辅助细胞和CRP正相关,与IgM负相关.
- 传统的pSS疗法没有显著影响AS事件.
结论:
- 在pSS患者中,AS的流行率很高 (41.3%).
- 疾病持续时间,B细胞,T辅助细胞和CRP是PSS中AS的重要危险因素.
- 免疫球蛋白M可能在pSS中对AS有保护作用.
- 目前的pSS治疗似乎无法预防AS的发展.
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