在T细胞急性淋巴细胞白血病患者的发病过程中,CXCL8 (IL-8) 的表达
Sandeep Pandey1, Ranjana Singh1, Nimra Habib1
1Biochemistry, King George's Medical University, Lucknow, IND.
Cureus
|October 27, 2023
概括
与健康个体相比,T细胞急性淋巴细胞白血病 (T-ALL) 患者的英特利乌金-8 (IL-8) 显著升高. 较高的IL-8水平与疾病晚期相关,这表明它有可能成为T-ALL.的诊断和治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 炎症是许多疾病的关键因素,包括动脉样硬化,心肌梗塞,败血症,类风湿性关节炎和癌症.
- 介乐-8 (IL-8) 是一种促炎性细胞因子,涉及各种病理过程.
研究的目的:
- 调查介质素-8 (IL-8) 水平与T细胞急性淋巴细胞白血病 (T-ALL) 之间的关联.
- 探索IL-8与T-ALL患者的疾病进展和临床病理参数的相关性.
主要方法:
- 52名参与者的IL-8水平量化 (26名T-ALL患者,26名健康对照).
- 使用流细胞计,酶相关免疫吸收试验 (ELISA),逆转录-聚合酶链反应 (RT-PCR) 和西部斑分析.
- 在基因组和蛋白质组两级评估IL-8.
主要成果:
- 与健康志愿者相比,在T-ALL患者中观察到显著更高的IL-8水平.
- 在基因组和蛋白质组水平上发现IL-8水平和T-ALL之间存在显著的正相关性.
- 血清IL-8水平升高与晚期疾病阶段和临床病理参数有关.
结论:
- 较高的血清IL-8水平与T-ALL的晚期疾病阶段有关.
- 监测IL-8可能有助于检测T-ALL的疾病.
- 在T-ALL.中,IL-8代表了新型诊断和治疗策略的潜在目标.
相关概念视频
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
T Cell Activation and Clonal Selection
764
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
764


