紫外光光谱学表征在脱离离子水中的布洛芬酸聚合物的紫外光光谱表征
Gregorio Marbán1, Amparo Fernández-Pérez1, Sonia Álvarez-García2
1Instituto de Ciencia y Tecnología del Carbono (INCAR-CSIC), c/Francisco Pintado Fe 26, 33011, Oviedo, Spain.
Heliyon
|October 27, 2023
概括
布洛芬酸在水中形成聚合物,而不是单体. 存在着二聚体,32个单位和128个单位的聚合物,其临界微粒度为7.8 ppm,影响溶解.
科学领域:
- 物理化学 物理化学
- 制药科学 制药科学
背景情况:
- 了解药物聚合对于配方至关重要.
- 布洛芬在水溶液中的行为需要详细的描述.
研究的目的:
- 为了研究ibuprofen酸在脱离离子水中的聚合平衡.
- 为了确定热力学参数和总体订单.
- 探索pH,导电性和布洛芬聚合之间的关系.
主要方法:
- 使用紫外线可见光谱法来监测聚合.
- 开发了一个计算算法来分析吸收率数据.
- 使用电导度测量来检测聚合物形成.
主要成果:
- 单质布洛芬酸不存在;观察到二元和较大的聚合物 (32,128个单位).
- 估计的临界菌度 (CMC) 为7.8 ppm.
- 聚合物形成与pH (pKa=4.62以下) 和电导率的增加有关.
结论:
- 布洛芬存在于水中的聚合物,而不是单体.
- 这项研究为ibuprofen聚合提供了热力学见解.
- 这些发现与ibuprofen溶解和配方优化有关.
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