介酶干细胞/介酶干细胞 - - 瘤微环境异质性的一个主要因素
1Department of Clinical Laboratory, Kunshan First People's Hospital, Affiliated to Jiangsu University, Kunshan, China.
Frontiers in immunology
|October 27, 2023
概括
瘤微环境 (TME) 中的介酶干/干细胞 (MSC) 驱动癌症的进展和治疗耐药性. 了解与癌症相关的MSC (CA-MSC) 为改善癌症治疗提供了新的治疗点.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 干细胞研究 干细胞研究
背景情况:
- 瘤微环境 (TME) 的异质性阻碍了有效的癌症治疗,往往导致息治疗.
- 介质细胞干/干细胞 (MSCs) 因其在TME内的复杂网络而与免疫疗法失败和癌症复发有关.
- 与癌症相关的MSCs (CA-MSCs) 在各种瘤类型中表现出强大的前瘤原生功能,但它们的起源仍然不清楚.
研究的目的:
- 审查来自TME的不同来源的CA-MSC的不同角色.
- 通过瘤微环境中的相互作用来阐明CA-MSCs的形成机制.
- 通过了解CA-MSC功能来确定抗癌策略的新型治疗点.
主要方法:
- 文献综述侧重于来自各种瘤来源的CA-MSCs.
- 对MSC在TME中的遗传和功能变化的现有证据的分析.
- 关于CA-MSC与瘤细胞和其他TME组件相互作用的信息的综合.
主要成果:
- CA-MSCs来自本地或招募的MSCs,这些MSC在与TME相互作用时经历了转变.
- 根据其组织来源,CA-MSCs的功能有很大差异.
- CA-MSCs在塑造整体TME和影响治疗结果方面发挥着至关重要的作用.
结论:
- CA-MSCs是瘤进展和治疗耐药性的关键参与者.
- 进一步研究CA-MSC的起源和功能对于开发有效的癌症疗法至关重要.
- 针对CA-MSCs为创新的抗癌治疗提供了一个有希望的途径.
更多相关视频
11:15A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
10.3K
07:20A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
Published on: February 28, 2020
10.0K
相关概念视频
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Mesenchymal Stem Cells
4.8K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.8K
Cancer Stem Cells and Tumor Maintenance
4.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K
Stem Cell Niche
5.1K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.1K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
3.5K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
3.5K
Stem Cell Therapy for Tissue Regeneration
4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
