相关实验视频

Updated: Jul 12, 2025

An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats

An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats

Published on: May 8, 2020

在左心室辅助装置植入后,身体质量指数依赖的免疫特征变化

Kristin Klaeske¹, Eva Katharina Messer¹, Sara Klein¹

¹University Clinic of Cardiac Surgery, Leipzig Heart Center, HELIOS Clinic, Leipzig, Germany.

Frontiers in immunology

|October 27, 2023

概括

在左心室辅助装置 (LVAD) 植入后,肥胖会改变免疫细胞种群,包括树突细胞 (DCs) 和T细胞. 肥胖患者的这些免疫变化可能会增加术后感染的风险.

科学领域:

免疫学免疫学免疫学
心血管外科心血管外科
移植手术移植手术

背景情况:

感染是左心室辅助器件 (LVAD) 植入后的一个重大并发症.
患有肥胖症的患者由于慢性炎症和相关的免疫学变化而存在更高的风险.
了解这些免疫变化对于管理术后感染风险至关重要.

研究的目的:

在LVAD植入后的第一年调查与身体质量指数 (BMI) 相关的免疫学参数的变化.
为了比较正常体重,前肥胖和肥胖患者后LVAD之间的免疫细胞种群.

主要方法:

血样采集在植入前,植入后3,6个月和12个月.
患者分为正常体重 (18.5-24.9 kg/m2),肥胖前期 (25.0-29.9 kg/m2) 和肥胖 (≥30.0 kg/m2) 的患者.
流细胞计用于分析CD4+ T细胞,CD8+ T细胞,调节性T细胞 (Tregs),B细胞和树突细胞 (DCs).

主要成果:

在LVAD后3个月,肥胖患者的整体DC比例较高.
在3个月前的肥胖和肥胖患者中观察到BDCA4+血细胞体DC的比例减少.
肥胖患者在6个月后表现出CD4+ T细胞增加和CD8+ T细胞减少.
在6个月和12个月前的肥胖患者中,Tregs的比例显著降低.

结论:

与正常体重个体相比,LVAD植入导致前肥胖和肥胖患者的明显免疫变化.
DCs,CD8+ T细胞和Tregs的变化表明与术后感染率增加的潜在联系.
这些发现凸显了在LVAD接受者中考虑BMI相关免疫状况的重要性.

关键词:

身体质量指数 (BMI) 是什么?树突细胞是一种树突细胞.免疫系统免疫系统左心室辅助装置的使用肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖监管T细胞的监管性T细胞

更多相关视频

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems

Published on: August 2, 2024

Implantation of the Syncardia Total Artificial Heart

Implantation of the Syncardia Total Artificial Heart

Published on: July 18, 2014

相关概念视频

Cardiomyopathy V: Interprofessional Care

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...

Cardiomyopathy II: Dilated Cardiomyopathy

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...