合成,超分子聚合,和NIR-II光的异二 ((i) zwitterions
Wenxuan Wei1, Jun Wang2, Xiaomei Kang1
1Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University Lanzhou 730000 China buwf@lzu.edu.cn.
Chemical science
|October 27, 2023
概括
研究人员使用不对称的协调方法开发了新的近红外II (NIR-II) 光异二zwitterions. 这些材料使得增强的体内瘤成像具有较长的循环时间.
科学领域:
- 材料科学 材料科学 材料科学
- 无机化学 无机化学
- 摄影化学的使用.
背景情况:
- 开发第二种近红外 (NIR-II) 光源 (1000-1700nm) 对于先进的成像技术至关重要.
- 具有NIR-II光的D8正方形平面金属复合物非常罕见.
- 现有的NIR-II发射器往往缺乏足够的亮度或稳定性用于体内应用.
研究的目的:
- 为了合成和表征新型NIR-II光异二. zwitterions.
- 为了研究这些zwitterions的聚合行为和光物理性质.
- 在NIR-II窗口中评估它们在体内瘤成像中的潜力.
主要方法:
- 不对称的协调范式,用于合成异和. zwitterions.
- 在溶液和聚合物纳米粒子中进行光谱分析 (吸收,排放).
- 评估聚合诱导的排放特性.
- 在瘤载体模型中的体内成像研究.
主要成果:
- 通过非对称的协调实现的NIR-II光异和 (i) 兹维特里昂的第一份报告.
- 兹维特里昂表现出强烈的聚合倾向,由金属对金属接触和π-π堆叠驱动.
- 在1005nm和1120nm (肩1210nm) 溶液中观察到的辐射,在聚合物纳米粒子中红移到1070nm和1130nm (肩1230nm).
- 聚合物纳米粒子在NIR-II区域的体内瘤中表现出有效的亮化,循环时间长.
结论:
- 不对称的协调策略成功地产生了新的NIR-II光异二.
- 高分子聚合在增强NIR-II光中发挥着关键作用.
- 这些在聚合物纳米颗粒中封装的zwitterions显示出对增强体内瘤成像的显著前景.
- 这项工作为设计各种NIR-II光开辟了新的途径.
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