草药配方对常见的口腔病原体具有抗菌活性
Remmiya Mary Varghese1, Subramanian Aravind Kumar1, S Rajeshkumar1
1Department of Orthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, Tamil Nadu.
Bioinformation
|October 27, 2023
概括
这项研究探讨了Ocimum gratissimum和Ocimum sanctum提取物的抗菌和细胞毒性作用. 协同配方表现出显著的细菌静止和抗真菌活性,对口腔病原体具有最小的细胞毒性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
- 民族植物学 民族植物学
背景情况:
- 抗生素耐药性是一个日益严重的全球健康问题,需要新的抗菌剂.
- 来自Ocimum gratissimum和Ocimum sanctum等植物的富含尤根醇的精油显示出作为天然抗菌剂的希望.
- 这些植物在传统印度医学中用于治疗各种疾病,包括感染,有着悠久的历史.
研究的目的:
- 评估由Ocimum gratissimum和Ocimum sanctum提取物衍生的联合配方的抗菌和细胞毒性潜力.
- 评估配方对常见的口腔病原体的疗效.
主要方法:
- 由O. gratissimum和O. sanctum植物提取物制成的配方制剂.
- 使用井扩散和汁稀释方法 (最小抑制度) 评估的抗菌活性.
- 细胞毒性通过盐水致死性试验进行评估.
主要成果:
- 该配方在100μL度下表现出对S. mutans,Enterococcus faecalis,C. albicans,Lactobacillus sp和S. aureus的细菌静止活性.
- 在阿加井扩散中没有观察到抑制区域,但注意到了细菌静止效应.
- 该配方在盐水杀伤性试验中显示出极小的细胞毒性.
- O. gratissimum和O. sanctum的协同作用增强了抗菌,抗真菌和细胞毒性活动.
结论:
- 在Ocimum gratissimum和Ocimum sanctum的协同配方具有显著的抗微生物和细胞毒性.
- 进一步的体内研究是有必要的,以探索这种天然配方的治疗潜力.
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