在口腔状细胞癌中的分子生物标志物NOTCH1,CD44,BMI1和TP53
Mohammad Reshma1, Roy Anitha2, Rajagopalan Vijayaraghavan1
1a Department of Research and Develpoment, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nādu.
Bioinformation
|October 27, 2023
概括
这项研究发现,与健康对照组相比,NOTCH1,CD44,BMI1和TP53基因表达在表皮,舌头和硬 palatus的口腔恶性瘤中显著升高. 这些基因可能作为潜在的早期生物标志物用于口腔癌检测.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 口腔恶性瘤 (OM) 在全球范围内构成重大健康负担.
- 识别可靠的口腔癌早期生物标志物对于改善患者的治疗结果至关重要.
- 不同口腔亚位点中NOTCH1,CD44,BMI1,TP53等特定基因的作用需要进一步调查.
研究的目的:
- 为了评估NOTCH1,CD44,BMI1和TP53基因在表皮,舌头和硬 palatus口腔恶性瘤中的表达水平.
- 将口腔癌患者的基因表达与健康对照进行比较.
- 探索基因表达与HPV状态和癌症T阶段的相关性.
主要方法:
- 一项前性,横截面研究,涉及60名口腔恶性瘤患者和健康对照.
- 用基因组测序来分析血液样本中NOTCH1,CD44,BMI1和TP53基因的表达.
- 统计分析包括使用Bonferroni的t测试进行单向ANOVA.
主要成果:
- 与对照组相比,口腔癌患者的NOTCH1,CD44,BMI1和TP53基因表达显著更高 (p < 0.001).
- 基因表达水平在上衣,舌头和硬 palatus 的子站点之间没有显著差异.
- 在较早的T阶段 (1和2) 与高级阶段 (3和4) 相比,NOTCH1的表达更高,而其他基因没有显示T阶段相关性. HPV 状态没有显著影响基因表达.
结论:
- 在口腔恶性瘤中NOTCH1,CD44,BMI1和TP53基因的高表达表明它们作为早期诊断生物标志物的潜力.
- 这些基因在不同的口腔亚位点中表达一致,并且在很大程度上独立于HPV状态.
- 进一步的研究可以验证这些基因用于口腔癌的早期检测和治疗向.
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