病毒激活和生态重组是太空飞行相关的免疫激活微生物组轴的特征
Braden T Tierney1,2, JangKeun Kim1,2, Eliah G Overbey1,2
1Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Research square
|October 27, 2023
概括
宇航员微生物组在太空飞行期间发生显著变化,影响健康. 这项研究揭示了微生物组的详细变化及其与机组人员免疫力的联系,这对未来的太空任务至关重要.
科学领域:
- 微生物学 微生物学
- 空间生物学 空间生物学
- 免疫学 免疫学 免疫学
背景情况:
- 太空飞行带来了与微生物组改变相关的健康风险.
- 限量采样阻碍了对太空飞行对微生物群的影响的理解.
研究的目的:
- 使用纵向研究量化高分辨率微生物群对太空飞行的反应.
- 为了描述微生物组的特征.
- 建筑 建筑学 建筑学 建筑学
- 在太空飞行期间穿越多个身体部位.
- 在太空飞行期间调查微生物组,宿主免疫和微生物基因表达之间的联系.
主要方法:
- 从十个身体部位的750个样本中对联的元基因组学和元转录学分析.
- 单个免疫分析,以评估宿主免疫反应.
- 菌株水平跟踪用于监测机组人员和环境中的微生物传播.
主要成果:
- 确定了依赖时间的,分类学上多样化的微生物组变化和泛类病毒激活.
- 观察到持续的变化,包括与免疫细胞基因表达相关的口腔病原生物.
- 发现微生物基因的普遍丰富与抗生素生产,毒素-抗毒素系统和应激反应有关.
- 在船员和航天器环境之间检测到微生物播种和传播.
- 微生物组变化和宿主免疫细胞变化之间的确立关联.
结论:
- 太空飞行引发了显著的,多地点的微生物组变化,病毒激活和持久的变化.
- 微生物组的变化与宿主免疫反应有关,这表明免疫变化的"微生物组轴".
- 这些发现为监测和调节宇航员微生物组以维持健康提供了基础.
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