在REM睡眠的前额叶皮层调节
Franz Weber1, Jiso Hong1, David Lozano1
1University of Pennsylvania.
Research square
|October 27, 2023
概括
中间前额叶皮层 (mPFC) 积极促进小鼠快速眼动 (REM) 睡眠. 这个大脑区域通过皮质-海马体通路调节REM睡眠及其独特的阶段性事件.
科学领域:
- 神经科学是一个神经科学.
- 睡眠研究 睡眠研究
- 皮层功能 皮层功能
背景情况:
- 快速眼动 (REM) 睡眠表现出高皮质脑电图 (EEG) 活动,类似于清醒状态.
- 雷姆睡眠诱导的神经起源主要归因于皮质下脑干和下丘脑电路.
- 皮层神经元在启动和调节REM睡眠中的潜在作用仍然在很大程度上未被探索.
研究的目的:
- 调查皮层神经元,特别是来自中间前额叶皮层 (mPFC) 的神经元,是否可以触发和调节REM睡眠.
- 阐明参与mPFC介导的REM睡眠调节的特定途径和神经元活动.
- 确定mPFC在控制REM睡眠期间阶段性事件中的作用.
主要方法:
- 在小鼠中利用光遗传学对激发性mPFC神经元活动的双向操纵.
- 通过电路追踪和操纵,研究了mPFC向侧向下丘脑 (LH) 的投影.
- 采用成像来监测LH投射mPFC神经元在REM睡眠和其阶段性事件期间的活动.
主要成果:
- 发现mPFC中的刺激神经元强烈促进REM睡眠.
- 对LH的mPFC投射调节REM睡眠,并与加速的EEG度振荡和增加的眼动密度有关.
- 大多数LH投射的mPFC神经元在REM睡眠期间表现出最大的激活,其中一小部分在阶段性太加速期间被招募.
结论:
- 确定了一种新的皮层-海马体电路,用于对REM睡眠的自上而下的控制.
- 确立了mPFC在促进REM睡眠和调节其相位特征方面的关键作用.
- 表明mPFC是控制REM睡眠启动和调节的神经回路中的关键节点.
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