联合铜和缺乏与BNT162b2疫苗接种的SARS-CoV-2免疫反应减少有关
Thilo Samson Chillon1, Kamil Demircan1, Julian Hackler1
1Max Rubner Center for Cardiovascular Metabolic Renal Research (CMR), Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Hessische Straße 3-4, D-10115 Berlin, Germany.
Heliyon
|October 27, 2023
概括
足够的铜和水平对于对mRNA疫苗产生强大的免疫反应至关重要. 这些微量元素的综合缺陷在接种疫苗后显著降低了SARS-CoV-2抗体标位.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 像铜,和这样的微量元素对免疫功能和疫苗有效性起着至关重要的作用.
- 微量营养素状态可能会影响疫苗诱导的免疫反应的有效性.
研究的目的:
- 为了研究血清微量元素水平 (铜,,) 和接种mRNASARS-CoV-2疫苗的医疗保健工作者疫苗诱导的抗体反应之间的联系.
- 为了确定铜和的联合缺陷是否会影响抗体标位和中和活性.
主要方法:
- 一项纵向研究涉及126名成人医疗保健工作者,他们接受了两剂BNT162b2 mRNA疫苗.
- 血清样本被纵向采集,以测量疫苗诱导的抗体,中和活性,以及铜,,和的度.
- 参与者根据基线血清微量元素水平进行了分类,特别关注铜和 (最低三角体) 的联合缺乏.
主要成果:
- 在接种疫苗后3周和6周,铜和综合缺乏症患者的抗体标位显著降低,相比于充足水平的患者.
- 具体来说",双重Q1"组 (组合缺乏症) 与"不双重Q1"组在两个时间点 (p <0.05) 中的抗体标位显著降低.
- 这项研究表明,微量营养素缺乏症对疫苗反应的协同作用.
结论:
- 足够的铜和血清水平对于在mRNA SARS-CoV-2疫苗接种后产生强烈的抗体反应很重要.
- 铜和的联合缺乏可能会损害疫苗的疗效,强调需要考虑在疫苗接种策略中微量营养素的状态.
- 需要进一步的研究来探索微量营养素缺乏症对疫苗诱导免疫力的影响.
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