过早出生,出生体重,以及随后的抑郁症风险
Neha Rahalkar1, Aaron Holman-Vittone1, Christian Daniele1
1Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA.
Journal of developmental origins of health and disease
|October 27, 2023
概括
低或高出生体重和早产与增加成人抑郁风险有关. 早期生活因素显著影响长期心理健康结果,这表明需要主动监测.
科学领域:
- 生殖健康 生殖健康
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 出生体重和早产是产前环境暴露的指标.
- 关于出生状态和成人抑郁症之间的关联的以前的研究是有限的.
- 妇女健康倡议 (WHI) 为调查这些联系提供了大量数据集.
研究的目的:
- 检查出生体重类别和早产状态与成人抑郁风险之间的关系.
- 评估早期生活因素与绝经后妇女心理健康结果之间的关联.
- 为了识别成年期抑郁症的潜在早期预测因素.
主要方法:
- 利用了女性健康倡议 (WHI) 中86,925名绝经后妇女的数据.
- 收集自我报告的出生体重 (类别) 和早产状态 (满期或早产).
- 评估使用伯纳姆屏幕,自我报告诊断和抗抑郁药物使用的抑郁症;用线性和逻辑回归模型分析.
主要成果:
- 出生时体重低 (<6磅) 或高 (≥10磅) 的个体的伯纳姆抑郁症得分明显更高.
- 低出生体重 (<6磅) 与患抑郁症的可能性更高有关 (adjOR 1.21).
- 过早分娩也与抑郁症风险增加有关 (adjOR 1.18),即使在低出生体重的个体中,这种关联也存在.
结论:
- 早期生活因素,包括出生体重和早产,与成年后抑郁症风险增加有关.
- 这些发现强调了早期暴露在塑造长期健康轨迹中的重要性.
- 有非最佳出生状态的个体可能会从有针对性的心理健康评估和持续的随访中受益.
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