一种简单的方法,通过双面图案来制造一个封闭的基于纸的分析设备,用于检测离子污染物
Jinsol Choi1, Eun-Ho Lee2, Sung-Min Kang2,3
1Department of Chemical and Biomolecular Engineering, Chonnam National University, 50 Daehak-ro, Yeosu 59626, Jeollanam-do, Republic of Korea.
Biosensors
|October 27, 2023
概括
这项研究引入了封闭的3D微流体基于纸的分析装置 (μPADs),以防止样品蒸发和污染. 这些新的μPAD能够快速,可靠地早期检测重金属和放射性离子.
科学领域:
- 材料科学与工程 材料科学与工程
- 分析化学 分析化学
- 微流体学 微流体学
背景情况:
- 传统的微流体纸质分析器件 (μPAD) 由于其开放通道设计而遭受样品蒸发和污染.
- 这些局限性阻碍了它们作为可靠的分析平台的应用,特别是在敏感的检测任务中.
- 需要封闭的μPAD设计来克服这些挑战并提高分析性能.
研究的目的:
- 设计和制造一个封闭的三维 (3D) -μPAD.
- 证明其作为离子污染物的首要早期分析平台的实用性.
- 为了优化制造参数,使用3D打印和聚二甲基 (PDMS) 模式创建封闭的微通道.
主要方法:
- 制造3D打印的印花模具,用于双面聚甲基 (PDMS) 图案.
- 控制PDMS透到纤维素基板上,以创建疏水性屏障和封闭的通道.
- 优化印花设计 (圆形,图案间距离10毫米) 和图案条件 (0.5分钟的接触时间,300微米的间距高度).
主要成果:
- 成功制造具有优化参数的封闭3D-μPAD.
- 在3分钟内同时对Ni2+,Cu2+,Hg2+和Cs+离子进行色度检测.
- 对Cs+的检测极限 (LOD) 达到0.016 ppm,在测试的离子度中具有高可靠性 (CV <3%).
结论:
- 附带的3D-μPAD有效地防止样品蒸发和污染,提高分析可靠性.
- 该平台为快速,灵敏和定量早期检测离子污染物提供了一个有前途的解决方案.
- 开发的3D-μPAD技术对环境和生物工业的应用有很大的潜力.
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