宿主防御和抗生素在对抗抗菌素耐药细菌方面的互补活动
Patrick R Lennard1,2,3,4, Pieter S Hiemstra3, Peter H Nibbering4
1Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK.
Antibiotics (Basel, Switzerland)
|October 27, 2023
概括
与抗生素相结合的宿主防御 (HDP) 显示出对抗生素耐药性 (AMR) 细菌感染的治疗有希望. 大多数组合显示出协同作用或添加作用,表明未来可行的治疗策略.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 主体防御 (HDP) 具有抗微生物和免疫调节性质,具有治疗细菌感染的潜力.
- 抗菌素耐药性 (AMR) 需要新的治疗方法,而HDP单一治疗不太可能成为一线治疗.
研究的目的:
- 批判性地审查最近关于HDP-抗生素组合对抗AMR细菌的抗菌活性的文献.
- 评估在评估HDP与抗生素组合的研究中使用的协同作用和方法.
主要方法:
- 对86项研究的系统性文献综述,重点关注针对AMR细菌的HDP-抗生素组合.
- 报告的相互作用 (协同作用,添加剂,冷漠作用,对抗作用) 和常见的抗生素类别和细菌物种的分析.
主要成果:
- 84.9%的评估组合显示出协同作用或添加作用,而15.1%是无关或对抗作用.
- 青素,aminoglycoside,/,和糖类抗生素经常被研究与HDPs对*金黄色葡萄球菌*,*Pseudomonas aeruginosa*,*Escherichia coli*,和*Enterococcus菌*.
- 有限的研究评估了生物膜,动物模型或高级组织感染模型中的组合.
结论:
- HDPs和抗生素的组合显示出治疗AMR细菌感染的巨大潜力.
- 需要进一步的研究来评估这些组合在更复杂的模型中,尽管目前的文献偏见.
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