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Updated: Jul 12, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Published on: March 27, 2020

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鉴定BRCC3和BRCA1作为TAZ稳定性和活动的调节者

Silvia Sberna1, Alejandro Lopez-Hernandez1, Chiara Biancotto1

  • 1Center for Genomic Science of IIT, CGS@SEMM (Istituto Italiano di Tecnologia at European School of Molecular Medicine), Fondazione Istituto Italiano di Tecnologia (IIT), 20139 Milan, Italy.

Cells
|October 27, 2023
PubMed
概括

研究人员确定了TAZ的新型调节剂,TAZ是细胞生长和癌症中的关键蛋白质. 发现BRCA1复杂组件BRCC3控制TAZ稳定性,这表明BRCA1突变可能通过激活TAZ驱动癌症.

关键词:
这就是BRCA1的原因.这就是BRCC3的原因.塔兹 (TAZ) 是一个名为塔兹 (TAZ) 的城市.在WWTR1中,WWTR1是WWTR1.一个YAP1一个YAP1在翻译后的法规.

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