在内源代谢物的分析中进行体积吸收微采样
Daniel Marques de Sá E Silva1,2, Marlene Thaitumu2,3, Georgios Theodoridis1,2
1Department of Chemistry, Aristotle University of Thessaloniki (AUTH), 54124 Thessaloniki, Greece.
Metabolites
|October 27, 2023
概括
卷度吸收微采样 (VAMS) 为生物分析提供了一种稳定而简单的方法. 这次审查突出了VAMS的重点.
科学领域:
- 生物医学分析分析
- 分析化学是一种分析化学.
- 发现生物标志物的发现.
背景情况:
- 体积吸收微采样 (VAMS) 越来越被认为可以简化生物样本采集并提高分析物的稳定性.
- 目前的VAMS应用主要集中在制药研究上,分析诸如药物,毒素和污染物等外源化合物.
- 在血液中分析内源生物标志物的VAMS的潜力仍然在很大程度上未被探索.
研究的目的:
- 综合审查VAMS设备用于分析内源代谢物和生物标志物的应用.
- 为整个VAMS分析过程提供详细的概述,包括样本处理和验证.
- 评估VAMS用于内源生物标志物分析的可靠性和优势.
主要方法:
- 用VAMS进行内源代谢物/生物标志物分析的研究的文献综述.
- 对基于VAMS的测定样品处理协议和验证参数的系统检查.
- 对VAMS性能与传统血液采样方法进行比较分析.
主要成果:
- VAMS设备在分析具有生物学意义的内源性分析物方面表现出可靠性.
- 使用VAMS进行微采样通常会提高与环境条件下的全血样本相比,分析物的稳定性.
- VAMS提供了一个方便而简单的样本采集模型.
结论:
- VAMS是一种可行且有效的技术,用于内源生物标志物分析.
- 简化程序和VAMS提供的更好的稳定性对生物研究有利.
- 对内源生物标志物的VAMS应用进行进一步的研究是有必要的.
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