使用选择性离子流管质谱和心力衰竭中的疾病严重程度的呼出呼吸分析
Wai Hong Wilson Tang1, Lily Tranchito2, Chonyang Albert1
1Heart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Metabolites
|October 27, 2023
概括
在心力衰竭 (HF) 患者中,高排气的乙和与较差的结果和较低的喷射分数相关. 这些挥发性有机化合物 (VOC) 的减少跟踪体重减轻,这表明它们有可能作为HF生物标志物.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 肺部医学 肺部医学
背景情况:
- 已知呼出的挥发性有机化合物 (VOC) 在心力衰竭 (HF) 中会发生变化.
- 挥发性有机物对长期心血管死亡率和发病率的预测价值仍需要独立验证.
- 乙和是对HF研究感兴趣的特定VOC.
研究的目的:
- 调查呼出的乙和水平与急性不补偿性心力衰竭 (ADHF) 中的临床参数之间的关联.
- 评估这些VOC与心脏病患者的运动能力之间的相关性.
- 为了确定是否呼出的乙和可以预测长期的不良心血管事件.
主要方法:
- 在55名ADHF患者的入院时和尿路后,测量出口气中的乙和.
- 评估了51名心脏病患者在运动前和运动高峰时接受心肺运动测试 (CPET) 的排气乙和.
- 与左心室喷射率 (LVEF),体重减轻,VE/VCO2,VO2峰值和长期不良事件相关的VOC水平.
主要成果:
- 在ADHF患者中,入院时的乙水平与较低的LVEF相关.
- 随着利尿症的增加,体重减轻的程度与酸盐和酸盐水平的显著降低相关.
- 在33个月内,基线乙和水平升高预测了复合不良事件 (死亡,VAD或移植) 的更高率.
- 乙和水平与CPET期间更高的VE / VCO2相关,但与峰值VO2无关.
结论:
- 呼出的乙与ADHF患者的较低LVEF和更差的预后有关.
- 呼出的乙和的减少与成功的利尿和体重减轻相关.
- 呼出的乙和作为新的,非侵入性的心力衰竭评估和预后生物标志物具有前景.
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