七周综合体育训练对超重/肥胖患者高密度脂蛋白功能的影响
Tiziana Bacchetti1, Camilla Morresi1, Gianna Ferretti2,3
1Department of Life and Environmental Sciences, Marche Polytechnic University, Via Brecce Bianche, 60131 Ancona, Italy.
运动训练通过增加抗氧化酶氧化酶-1 (PON1) 活性和降低髓氧化酶 (MPO) 水平,改善了超重/肥胖成年人的HDL功能. 这增强了HDL.
科学领域:
- 运动生理学 运动生理学
- 心血管健康的心血管健康
- 代谢综合征是代谢综合征.
背景情况:
- 超重/肥胖与HDL功能受损和氧化应激增加有关.
- 高密度脂蛋白 (HDL) 在逆胆固醇运输中起着至关重要的作用,并具有抗氧化特性.
- 运动是控制肥胖和改善心血管风险因素的基石干预措施.
研究的目的:
- 为了研究7周监督运动计划对超重/肥胖成年人的HDL组成和功能的影响.
- 评估抗氧化酶偏氧酶-1 (PON1) 活性和氧化应激标记物的变化.
- 为了将运动诱导的变化与心肺健康和身体组成的改善相关联.
主要方法:
- 18名超重/肥胖的受试者 (BMI 30.3 ± 3 kg/m2) 接受了为期7周的联合抵抗和调节训练计划.
- 在干预前和后测量了血清中偏氧酶-1 (PON1) 活性,髓氧化酶 (MPO) 水平,氧化低密度脂蛋白 (ox-LDLs) 和总抗氧化能力.
- 评估了肌肉力量,最大氧气摄取量 (VO2max),体重,BMI,脂肪组织质量和腰围.
主要成果:
- 运动训练显著增加了与高脂相关的PON1活性 (p < 0.0001),并降低了MPO水平和MPO/PON1比率 (p < 0.0001).
- 观察到肌肉强度和VO2max (p < 0.0001) 的显著改善,以及总和内脏脂肪组织和腰围的减少 (p < 0.001).
- 在血清MPO/PON比率,HDL氧化还原活性和牛-LDLs之间发现了显著的相关性.
结论:
- 监督的运动训练有效地提高了超重/肥胖成年人的HDL功能,独立于饮食变化.
- 提高HDL的抗氧化能力和减少MPO有助于减少氧化应激.
- 这项研究强调运动是改善心血管健康标志物的有效策略,即使没有显著的体重减轻.
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