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临床T4直肠癌的指导与非指导基础的新辅助管理

Xi Chen^1,2, Xinyu Xie^1,2, Xiaodong Wang¹

¹Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.

Current oncology (Toronto, Ont.)

|October 27, 2023

概括

临床T4直肠癌 (RC) 治疗指南的遵守率很低. 目前遵守新辅助疗法指南似乎无法改善这些患者的整体存活率或疾病特定存活率.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
胃肠病学胃肠病学

背景情况:

实践指南建议用于临床T4直肠癌 (RC) 的新辅助治疗.
评估遵守这些指导方针及其对患者结果的影响至关重要.
了解准则遵守和死亡率的预测因素对于改善护理至关重要.

研究的目的:

评估遵守新辅助治疗指南与临床T4RC.患者结果之间的相关性.
为了确定准则遵守的预测因素.
确定与临床T4RC患者死亡率相关的因素.

主要方法:

对397名临床T4RC患者 (2017-2020年) 的回顾性研究.
根据遵守新辅助治疗指南对患者进行分类.
分析总生存率 (OS) 和疾病特异性生存率 (DSS) 作为主要终点.

主要成果:

准则的遵守率很低,为39.55%.
不按照指导方针进行的新辅助治疗没有显示出生存益处 (OS: 95.7% vs. 88.9%;DSS: 96.3% vs. 91.1%).
与死亡风险增加相关的因素包括第三阶段,中高差异化和客观遵守.

结论:

遵守临床T4RC的新辅助疗法指南是不理想的.
目前的准则遵守似乎没有改善临床T4RC患者的生存结果.
需要进一步的研究来优化临床T4 RC的治疗策略.

关键词:

这是一个指导方针.新辅助疗法是一种新辅助疗法.这是直肠癌.

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