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生物仿真酸牙膏诱导的人类牙上的重矿化

Alexandra-Diana Florea¹, Lucian Cristian Pop¹, Horea-Rares-Ciprian Benea²

¹Research Center of Physical Chemistry, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, 11 Arany Janos Str., 400028 Cluj-Napoca, Romania.

Biomimetics (Basel, Switzerland)

|October 27, 2023

概括

测试了四种新的纳米-酸酸盐 (HAP) 牙膏,以检测牙质的重矿化. 含有HAP-Mg-Zn-Sr-Si的P3牙膏在修复牙质上显示出最显著的结果.

科学领域:

生物材料科学生物材料科学
牙科材料牙科材料
纳米技术纳米技术

背景情况:

牙损仍然是一个重要的全球健康问题.
重矿化策略对于管理早期的面膜去矿化至关重要.
在牙科护理产品中,纳米酸 (Nano-hydroxyapatites,简称HAPs) 是有前途的活性剂.

研究的目的:

评估四种新型纳米-基亚帕提特牙膏在人类牙上的重矿化功效.
为了比较纯和生物模拟替代HAPs对质表面性能的影响.

主要方法:

人类质切片被人为地去矿化,每天处理十天.
使用原子力显微镜 (AFM) 进行了表面分析,以确定表面粗度 (Ra).
通过X射线衍射 (XRD) 和富里埃变换红外光谱 (FTIR) 检测HAP的结构和粒子大小.

主要成果:

牙膏P3 (HAP-Mg-Zn-Sr-Si) 显示出最高的再生矿物效应,这是10天后最低的平均表面粗度所表明的.
HAP颗粒大小在30-40纳米之间,晶体大小在28-33纳米之间,晶度在29-37%之间.
有效性排名是P3 = P2 (HAP) > P4 (HAP-Mg-Zn-Si) > P1 (HAP-Zn). 在这种情况下,有效性排名是P3 = P2 (HAP) > P4 (HAP-Mg-Zn-Si) > P1 (HAP-Zn).

结论:

生物模拟替代纳米-酸牙膏,特别是P3,在重矿化人类牙上是有效的.
这些新的HAP配方显示出早期牙的成功治疗的潜力.
化学成分和纳米颗粒大小显著影响重矿化能力.

关键词:

在X射线衍射 (XRD) 中.原子力显微镜 (AFM) 的使用结晶性结晶性是指结晶性.脱矿化脱矿化面膜面膜是指面膜的面膜.氧帕提特是一种氧帕提特.表面的粗度表面的粗度

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