提高分类器性能使用群体智能从胰腺微阵列基因数据检测糖尿病
Dinesh Chellappan1, Harikumar Rajaguru2
1Department of Electrical and Electronics Engineering, KPR Institute of Engineering and Technology, Coimbatore 641 407, Tamil Nadu, India.
Biomimetics (Basel, Switzerland)
|October 27, 2023
概括
这项研究利用胰腺基因数据增强了糖尿病检测能力. 特性选择和缩小尺寸的技术显著提高了分类器的准确性,达到95.714%.
科学领域:
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
背景情况:
- 糖尿病检测通常依赖于复杂的基因表达数据.
- 高维微阵列数据为准确分析带来了挑战.
- 有效的尺寸缩小和特征选择对于提高诊断准确性至关重要.
研究的目的:
- 从胰腺微阵列基因数据来研究各种缩小维度 (DR) 和特征选择技术的有效性,以检测糖尿病.
- 为了比较多个分类算法在识别糖尿病的性能.
- 确定DR和特征选择方法的最佳组合,以提高诊断准确度.
主要方法:
- 应用的缩小维度的技术:贝塞尔函数,离散等边变换 (DCT),最小平方线性回归 (LSLR) 和人工藻类算法 (AAA).
- 采用元启发式算法来进行特征选择:龙优化算法 (DOA) 和大象群优化算法 (EHO).
- 使用的分类器包括支持向量机 (SVM) 与线性,多项式和辐射基函数 (RBF) 内核,物流回归 (LoR) 等,评估性能指标,如精度,F1得分和MCC.
主要成果:
- 支持向量机 (SVM) 具有辐射基函数 (RBF) 内核,使用人工藻类算法 (AAA) 减小维度而没有特征选择,实现了90%的准确性.
- 结合人工藻类算法 (AAA) 来减少维度和大象群群优化算法 (EHO) 来选择特征,加上SVM (RBF),获得了最高的准确率95.714%.
- 跨各种指标的性能分析证实了特征选择对分类器性能的重大影响.
结论:
- 特征选择方法在从基因表达数据中提高糖尿病检测的准确性方面发挥着至关重要的作用.
- 拟议的方法结合了先进的DR和特征选择技术,为改进的诊断工具提供了一个有希望的途径.
- 这项研究突出了计算方法在精准医学中的潜力,用于治疗糖尿病等复杂疾病.
相关概念视频
01:11Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
01:29Hyperglycemia
Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...