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来自保加利亚南部的血液透析患者中感染E型肝炎病毒 (HEV)

Ani Kevorkyan¹, Elitsa Golkocheva-Markova², Ralitsa Raycheva³

¹Department of Epidemiology and Disaster Medicine, Faculty of Public Health, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.

Pathogens (Basel, Switzerland)

|October 27, 2023

概括

在血液透析患者中,E型肝炎病毒 (HEV) 血清流行率为10.7%. 更长的透析时间和血管接入增加了HEV风险,而瓶装水的消费与较低的HEV IgG水平有关.

科学领域:

病毒学病毒学
腎臟病學 (nephrology) 是一種醫學專業.
流行病学流行病学

背景情况:

B型肝炎和C型肝炎在血液透析 (HD) 患者中很常见.
型肝炎病毒 (HEV) 越来越多地被认可,但其在疾病发病患者中的血清流行率尚不清楚.
相互矛盾的全球数据需要进一步调查这个人群中的HEV.

研究的目的:

确定保加利亚血液透析患者中HEV的血清流行率.
在这个队列中确定与HEV血清阳性相关的预测因子.
分析HEV血清流行率与饮用水的习惯之间的关系.

主要方法:

一项涉及2020年保加利亚南部225名血液透析患者的横截面研究.
与酶相关的免疫吸收试验 (ELISA) 用于抗HEV IgM/IgG检测.
用于预测器识别的HEV RNA测试和后勤回归分析.

主要成果:

总体HEV血清流行率为10.7% (24/225).
单独使用抗HEV IgM:2.7%;单独使用抗HEV IgG:6.2%;两者:1.8%. 所有患者都是HEV RNA阴性.
增加HEV风险的预测因素包括血管接入和透析持续时间>5年. 瓶装水的消费与较低的HEV IgG水平相关.

结论:

在保加利亚的血液透析患者中存在HEV感染.
透析持续时间和血管通道是HEV的重要风险因素.
瓶装水的消费可能是预防HD患者对HEV IgG血清阳性的一种保护因素.

关键词:

高高温病毒的流行率血液透析患者进行血液透析.血清阳性的预测因素

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